4 Surprising Clinical Studies on Hypochlorous Acid (HOCl)

Let’s delve into the intricate world of hypochlorous acid (HOCl) and its fascinating properties. Its potential as a versatile disinfectant has been well-documented, but recent clinical research has unveiled a host of other exciting applications for this incredible molecule.


In today’s post, we explore some of the unexpected clinical discoveries that feature a molecule found in all of our bodies’ white blood cells: hypochlorous acid (HOCl).

HOCl, often known for its unique combination of possessing strong antimicrobial properties while remaining as safe to healthy tissue as saline, has been the subject of numerous research studies. These studies have revealed a host of surprising and groundbreaking findings.

From wound healing to skincare, we present four remarkable clinical studies that shed light on the astonishing potential of this unassuming yet powerful compound. Prepare to be intrigued at the diverse applications and benefits of HOCl, backed by scientific evidence that challenges conventional wisdom and opens up new possibilities in the field of healthcare.

Acne on face

1. Acne Vulgaris

Considering the efficacy of HOCl as a wound treatment, it’s unsurprising that this antibacterial, anti-fungal, and anti-inflammatory powerhouse would be studied for other dermatological applications.

In this case, a pilot study aimed to evaluate the effectiveness and tolerability of two novel proprietary treatments based on pure hypochlorous acid (HOCl) for individuals with mild-to-moderate acne vulgaris¹. The research involved a total of 50 participants who were administered the HOCl-based treatments over a specified period.

The results demonstrated promising efficacy in reducing acne lesions and improving overall skin condition. Moreover, the treatments were well-tolerated with minimal side effects reported. This preliminary study suggests that HOCl-based therapies hold potential as a safe and effective option for managing mild-to-moderate acne vulgaris, warranting further investigation in larger clinical trials.

Bandage on knee

2. Post-Procedural Scarring

This study explores the impact of hypochlorous acid gel technology on post-procedure treatment and scar prevention.

In 2017, Gold et al. conducted research to investigate the efficacy of HOCl gel in managing various post-procedure wounds and reducing the likelihood of scar formation². The study involved a cohort of patients undergoing different cosmetic procedures.

The results demonstrated that the application of HOCl gel significantly improved wound healing outcomes and minimized the appearance of scars. The gel's properties showed excellent tolerability and safety, making it a promising option for post-procedure care. This research highlights the potential of HOCl gel technology as a valuable addition to the dermatologist's toolkit, ensuring better patient outcomes and enhancing the overall success of cosmetic procedures.

Breast implant surgery tray

3. Breast Implant Pocket Infections

In a study conducted by Hu et al. (2018), researchers aimed to compare the effectiveness of two antiseptic solutions, hypochlorous acid (HOCl), and povidone-iodine (PI), for breast implant pocket irrigation during surgery³.

Researchers conducted a comparative analysis by evaluating the antimicrobial properties of both solutions in vitro. They examined their efficacy against common bacteria found in breast implant pocket infections to determine which antiseptic was more effective for irrigation.

The results of the study showed that hypochlorous acid and povidone-iodine both exhibited significant antimicrobial activity against the tested bacteria. However, the researchers found that HOCl demonstrated superior efficacy compared to povidone-iodine in terms of its ability to eliminate bacteria commonly associated with breast implant infections. Therefore, the study suggests that hypochlorous acid may be a more effective choice as an antiseptic for breast implant pocket irrigation during surgery, potentially reducing the risk of post-operative infections.

Nevertheless, further research and clinical studies would be necessary to validate these findings and assess the safety and practicality of using HOCl for breast implant pocket irrigation in real surgical settings.

Removing dental plaque from a patient

4. Dental Plaque Formation

The study conducted by Lafaurie et al. (2018) aimed to assess the substantivity of hypochlorous acid (HOCl) as an anti-plaque agent⁴.

The researchers conducted a randomized controlled trial to evaluate the ability of HOCl to provide long-lasting antibacterial effects in the oral cavity. Participants were randomly assigned to use either a mouthwash containing HOCl or a placebo mouthwash for a specified period.

Throughout the trial, the researchers measured the reduction of plaque formation and the presence of bacteria in the oral cavity. The results showed that the group using the mouthwash containing HOCl demonstrated significantly lower plaque formation and bacterial levels compared to the placebo group. This indicates that HOCl exhibited substantivity as an anti-plaque agent, offering long-lasting antibacterial effects even after the mouthwash use had ceased.

The findings suggest the potential usefulness of HOCl as an effective and durable agent for oral hygiene and plaque control. However, further research and longer-term studies are necessary to validate these results and establish the safety and clinical relevance of using HOCl as an anti-plaque agent in routine oral care.

Final Thoughts

Expert evaluations of the clinical applications of HOCl are continuously evolving, demonstrating the solution's diverse range of therapeutic uses, from dermatological skin applications to wound, eye, and dental care. The study of HOCl consistently reveals incredible discoveries, with new ones always on the horizon.

If you're interested in learning more about existing research on HOCl, check out our research repository, where we keep you up-to-date on the latest clinical literature and case studies featuring HOCl.

If you’d like to connect with us directly to learn more about the benefits of HOCl in your life or practice, please contact us.


  1. Nestor, M. S., Berman, B., Patel, J., Lawson, A., Jones, J. L., & Matin, T. A pilot study to assess the efficacy and tolerability of two new proprietary, pure hypochlorous acid-based (HOCl) treatments for mild-to-moderate acne vulgaris.
  2. Gold, M. H., Andriessen, A., Dayan, S. H., Fabi, S. G., Lorenc, Z. P., & Henderson Berg, M. H. (2017). Hypochlorous acid gel technology—Its impact on postprocedure treatment and scar prevention. *Journal of cosmetic dermatology, 16(2), 162-167.
  3. Hu, H., Sleiman, J., Johani, K., & Vickery, K. (2018). Hypochlorous acid versus povidone-iodine containing irrigants: which antiseptic is more effective for breast implant pocket irrigation?. Aesthetic Surgery Journal, 38(7), 723-727.
  4. Lafaurie, G. I., Zaror, C., Díaz‐Báez, D., Castillo, D. M., De Ávila, J., Trujillo, T. G., & Calderón‐Mendoza, J. (2018). Evaluation of substantivity of hypochlorous acid as an antiplaque agent: a randomized controlled trial. International Journal of Dental Hygiene, 16(4), 527-534.

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