The Advantages of Gel-Based Hypochlorous Acid

Exploring the massive potential of gel-based hypochlorous acid (HOCl) formulations, we look at how this innovative approach is making strides in wound care, eye care, and dermatology, offering unique advantages and improved effectiveness. A must-read for healthcare professionals interested in the latest innovations in pure, stable HOCl.


One truth always remains steadfast: Science moves forward.

With new ideas and breakthroughs happening every day, one of the latest developments in the realm of antiseptics is a substance in gel form that contains hypochlorous acid. Solutions in this arena represent an important step forward for treating wounds, eye problems, and skin conditions. Gel formulations are getting plenty of attention not only from the scientific community, but also the clinical community since it can be used in very specific applications that ultimately benefit the patient.

Aqueous hypochlorous acid is known for being highly effective at killing harmful microbes. In this relatively novel gel form, it can be used even more effectively to meet specialized healthcare needs. Let's take a closer look at this in the context of wound healing and eye health.

What is Gel-Based Hypochlorous Acid (HOCl)?

A gel-based Hypochlorous Acid (HOCl) formula is an innovative method of producing a product that incorporates HOCl, a potent antimicrobial agent, into a gel consistency. Since hypochlorous acid is a very reactive molecule, it can be difficult for inexperienced or under-equipped manufacturers to ensure stability of the HOCl within the gel itself.

However, once successful, the clinical benefits speak for themselves. Unlike traditional liquid HOCl solutions, the gel's unique viscosity allows for prolonged contact on specific surfaces, making it particularly advantageous for applications such as wound care, where controlled and sustained release of HOCl is essential for effective antimicrobial treatment¹. This breakthrough in formulation enhances the versatility and precision of HOCl, offering a valuable solution in various healthcare settings¹.

To Gel, or Not to Gel…

While gel-based Hypochlorous Acid (HOCl) introduces a noteworthy advancement in targeted application compared to traditional liquid solutions, it's important to note that one is not inherently superior to the other. The choice between gel and liquid HOCl depends on the specific application.

Gel formulations excel in scenarios where prolonged contact or adherence to surfaces is crucial, making them particularly suitable for wound care and eye care. Aqueous HOCl, on the other hand, may be more practical for applications where a traditional liquid antiseptic or saline may be used, such as pressurized wound cleaning. Combining both formats strategically allows for a comprehensive approach, leveraging the strengths of each². This synergistic utilization ensures a versatile and advantageous solution, where the unique properties of gel and liquid HOCl complement each other, catering to a wide range of healthcare needs with enhanced precision and efficacy².

Exploring the Existing Clinical Applications of Gel-Based HOCl Formulations

Hypochlorous Acid Gel Technology in Dermatologic & Post-Surgical Applications

This clinical overview by dermatological research is focused on determining the best pre- and post-procedural regimen for infection prevention, inflammatory reduction, and scar risk mitigation¹. Researchers investigated the role of new gel technology hypochlorous acid and a modified silicon oil, in post-treatment applications, specifically in order to prevent infection and reduce risk of post-procedural scarring¹.

Through a literature review and expert panel discussions with dermatologists and plastic surgeons, the study highlighted the safety and efficacy of hypochlorous acid products, produced through electrolysis and classified among biocidal substances¹. The technology demonstrated comparable safety to standard local antiseptics, and small-scale studies suggested superior outcomes with the scar gel compared to silicone gel, particularly in addressing hypertrophic and keloid scars, as well as providing relief from associated pruritus and pain¹. The study concludes that a post-procedure regimen incorporating this technology appears to be effective, safe, and well-tolerated, offering potential advantages over current practices¹.

Chronic Ulcers & Bi-Treatment with Hypochlorous Acid Gel & Liquid

In a non-randomized experimental study involving 220 patients with 346 chronic ulcers of diverse etiologies, researchers investigated the efficacy of various antiseptic solutions in wound healing². The study² revealed that patient age, weeks of ulcer evolution, poor granulation on admission, and the need for antibiotic therapy were factors associated with reduced probability of complete ulcer healing.

Interestingly, the use of a combined Hypochlorous Acid (HOCl) therapy² involving both liquid and gel forms significantly favoured healing, with an odds ratio of 4.8. Infections were linked to longer ulcer evolution times and bad odour upon admission, but the application of HOCl bi-treatment substantially reduced the risk of infection². The findings suggest that a dual HOCl formulation (liquid plus gel) holds promise in improving outcomes for chronic ulcers of various origins, mitigating the risks of poor healing and infection².

Final Thoughts

In exploring the innovative landscape of hypochlorous acid formulations, it becomes evident that both gel-based and spray hypochlorous acid formulations offer promising advancements in various healthcare applications¹⁻².

The gel-based HOCl stands out for its enhanced stability and targeted application, particularly beneficial in wound care and post-procedural applications¹⁻². Moreover, studies emphasize the significance of a dual HOCl formulation, combining liquid and gel, showcasing its potential to reduce the probability of poor healing and infection in chronic ulcers².

On another front, the use of hypochlorous acid-containing spray and translucent scar gel presents a compelling solution for pre- and post-procedural care, demonstrating efficacy, safety, and superior outcomes in scar management compared to traditional silicone gel¹.

Collectively, these findings underscore the versatility of hypochlorous acid formulations, offering a nuanced approach to wound care, infection prevention, and scar management in the ever-evolving landscape of medical science.


  1. Gold, M. H., Andriessen, A., Dayan, S. H., Fabi, S. G., Lorenc, Z. P., & Henderson Berg, M. H. (2017). Hypochlorous acid gel technology—Its impact on postprocedure treatment and scar prevention. Journal of cosmetic dermatology, 16(2), 162-167.
  2. Herruzo, R., Fondo Alvarez, E., Herruzo, I., Garrido‐Estepa, M., Santiso Casanova, E., & Cerame Perez, S. (2023). Hypochlorous acid in a double formulation (liquid plus gel) is a key prognostic factor for healing and absence of infection in chronic ulcers. A nonrandomized concurrent treatment study. Health Science Reports, 6(10), e1497.

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