Hypochlorous Acid as a Potential Postsurgical Antimicrobial Agent in Periodontitis: A Randomized, Controlled, Non-Inferiority Trial.
Published
Jul 18, 2024
Plata, J. C., Díaz-Báez, D., Delgadillo, N. A., Castillo, D. M., Castillo, Y., Hurtado, C. P., ... & Lafaurie, G. I. (2023). Hypochlorous Acid as a Potential Postsurgical Antimicrobial Agent in Periodontitis: A Randomized, Controlled, Non-Inferiority Trial. Antibiotics, 12(8), 1311.
This study showed a similar reduction of the mean of PD [pocket depth] and CAL [clinical attachment level] in CHX and HOCl protocols. However, in gain >3 mm of CAL, HOCl tended to show a significant reduction compared to CHX. We could hypothesize that reducing the recolonization of periodontal microorganisms may favor tissue healing. However, HOCl has been shown to have an anti-inflammatory effect in atopic dermatitis, and it is favored when combined with taurine. The anti-inflammatory effect of HOCl could also be related to the improvement of healing of periodontal tissues, unlike the CHX, which has been associated with a delay in the proliferation of gingival fibroblasts and the production of collagenous and non-collagenous proteins.
References
Plata, J. C., Díaz-Báez, D., Delgadillo, N. A., Castillo, D. M., Castillo, Y., Hurtado, C. P., ... & Lafaurie, G. I. (2023). Hypochlorous Acid as a Potential Postsurgical Antimicrobial Agent in Periodontitis: A Randomized, Controlled, Non-Inferiority Trial. Antibiotics, 12(8), 1311.
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