Influence of acidic pH on wound healing in vivo: A novel perspective for wound treatment
Published
Feb 13, 2023
Sim, P., Strudwick, X. L., Song, Y., Cowin, A. J., & Garg, S. (2022). Influence of acidic pH on wound healing in vivo: a novel perspective for wound treatment. International Journal of Molecular Sciences, 23(21), 13655.
Acidification of the wound by acidic buffers was found to be an effective strategy to improve wound healing. A significant improvement in wound healing parameters was observed as early as 2 days post-treatment with acidic buffers compared to controls, with faster rate of epithelialization, wound closure and higher levels of collagen at day 7. pH is shown to play a role in mediating the rate of wound healing, with acidic buffers formulated at pH 4 observed to stimulate faster recovery of wounded tissues than pH 6 buffers. Our study shows the importance of maintaining an acidic wound microenvironment at pH 4, which could be a potential therapeutic strategy for wound management.
References
Sim, P., Strudwick, X. L., Song, Y., Cowin, A. J., & Garg, S. (2022). Influence of acidic pH on wound healing in vivo: a novel perspective for wound treatment. International Journal of Molecular Sciences, 23(21), 13655.
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